Rauwolfia serpentina toxicity in a dog

To describe the clinical manifestations and treatment of Rauwolfia serpentina toxicity in a dog. A 9-month-old intact male mixed breed dog was presented following ingestion of an antihypertensive medication containing alkaloids from R. serpentina. R. serpentina alkaloids cause depletion of the biolo...

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Bibliographic Details
Published in:Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2008-12, Vol.18 (6), p.654-658
Main Authors: Good, Jennifer M, Mandell, Deborah C
Format: Article
Language:English
Subjects:
catecholamines
hypotension
raunatin
sedation
serotonin
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Summary:To describe the clinical manifestations and treatment of Rauwolfia serpentina toxicity in a dog. A 9-month-old intact male mixed breed dog was presented following ingestion of an antihypertensive medication containing alkaloids from R. serpentina. R. serpentina alkaloids cause depletion of the biologic amines: norepinephrine, dopamine, and serotonin. The dog experienced hypotension, mental depression, bradycardia, diarrhea, bronchoconstriction, and gastrointestinal ulceration similar to the adverse effects reported in humans. The dog was released from the hospital after 4 days of supportive care. This is the first case of accidental R. serpentina toxicity in a dog reported in the literature. This case had a good clinical outcome with supportive care and monitoring of all the subsequent adverse effects.
ISSN:1479-3261
1476-4431
DOI:10.1111/j.1476-4431.2008.00367.x