Unlocking the Chemotherapeutic Potential of b-Aminovinyl Ketones and Related Compounds

• Published in: ChemMedChem 2009-07, Vol.4 (7), p.1043-1050
• Main Authors: Gaber, Hatem M, Bagley, Mark C
• Format: Article
• Language: ger
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200900006

The role of -aminovinyl ketones as synthetic intermediates has been well categorised, but recent developments have shown an interesting array of applications and new chemotherapeutic potential, both in the preparation of biologically active heterocycles and as pharmacophores in their own right. Medicinal chemists are accustomed to using the products of Knoevenagel-type condensations as auxiliaries for the synthesis of N-containing heteroaromatic compounds. One such example of these chemical building blocks are -aminovinyl ketones - valuable synthetic intermediates that have been used in the preparation of pyridines, pyrimidines, pyrazoles, and many other heterocyclic motifs. This review highlights their recent use in the synthesis of biologically active targets as part of drug discovery programmes and in natural product synthesis. However, it is becoming increasingly evident that the enaminone motif may serve as a therapeutic pharmacophore in its own right. This review highlights the range of biological responses that -aminovinyl ketones elicit, including as antitumour, antibacterial, and anticonvulsant agents. Thus, with a broad spectrum of biological properties and as versatile chemical intermediates, it is clear that -aminovinyl ketones offer great potential in the search for new chemotherapeutic agents.