Pulmonary and Systemic Defenses against Challenge with Staphylococcus aureus in Mice with Pneumonia Due to Influenza A Virus

Pulmonary and systemic defenses against hematogenous challenge with 32P-labeled Staphylococcus aureus were measured 10 min, 8 hr, and 24 hr after intravenous injection of the bacteria in a mouse model of influenza virus pneumonia. Infection with influenza A virus did not alter bactericidal defenses...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1979-07, Vol.140 (1), p.105-108
Main Authors: Jakab, George J., Warr, Glenn A., Knight, Mardel E.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Infections
Influenza A virus
Influenza A virus - immunology
Liver
Liver - immunology
Lung - immunology
Lung - pathology
Lungs
Mice
Mononuclear Phagocyte System - immunology
Orthomyxoviridae
Pneumonia - etiology
Pneumonia - prevention & control
Spleen
Spleen - immunology
Staphylococcus
Staphylococcus aureus - immunology
Viruses
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pulmonary and systemic defenses against hematogenous challenge with 32P-labeled Staphylococcus aureus were measured 10 min, 8 hr, and 24 hr after intravenous injection of the bacteria in a mouse model of influenza virus pneumonia. Infection with influenza A virus did not alter bactericidal defenses in the liver and spleen, but pulmonary bactericidal activity measured 24 hr after infection was suppressed in virus-infected animals; 20% ± 3% of the initially injected, viable bacteria were recovered from lungs of pneumonitic mice after 24 hr as compared with 9% ± 1% from lungs of the un infected mice. These data demonstrate that pulmonary infection with influenza virus does not alter antibacterial defenses of the liver and spleen but does suppress bactericidal activity in the lung.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/140.1.105