Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action

• Published in: Journal of ethnopharmacology 2010-02, Vol.127 (2), p.508-514
• Main Authors: Mazzolin, Lucilene Patrícia, Nasser, Ana Lúcia Martiniano, Moraes, Thiago Mello, Santos, Raquel Cássia, Nishijima, Catarine Massucato, Santos, Fábio Vieira, Varanda, Eliana Aparecida, Bauab, Taís Maria, da Rocha, Lúcia Regina Machado, Di Stasi, Luis Cláudio, Vilegas, Wagner, Hiruma-Lima, Clélia Akiko
• Format: Article
• Language: English
• Subjects: analgesic effect; animal models; animal pathogenic bacteria; Animals; Anti- Helicobacter pylori; anti-ulcer activity; Anti-Ulcer Agents - isolation & purification; Anti-Ulcer Agents - pharmacology; Anti-Ulcer Agents - therapeutic use; antibacterial properties; Antidiarrheals - isolation & purification; Antidiarrheals - pharmacology; Antidiarrheals - therapeutic use; bark; Biological and medical sciences; diarrhea; dosage; dose response; ethnobotany; Female; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; Gastric protection; General pharmacology; Glutathione; Helicobacter pylori; Helicobacter pylori - drug effects; Helicobacter pylori - physiology; hemorrhage; Hemostatics - isolation & purification; Hemostatics - pharmacology; Hemostatics - therapeutic use; inflammation; lipid peroxidation; Male; Medical sciences; medicinal plants; medicinal properties; Mice; mutagenesis; Mutagenicity Tests - methods; pain; PGE 2 level; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants, Medicinal; protective effect; Qualea parviflora; Qualea parviflora Mart; Rats; Rats, Wistar; traditional medicine; Vochysiaceae
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2009.10.005

Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome. Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti- Helicobacter pylori activities. The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti- Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora. QP (500 mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-dependent inhibition effect on the lipid peroxidation. QP present anti- Helicobacter pylori effect (MIC = 75 μg/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect. methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE 2 levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti- Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use.