No association between the FXYD6 gene and schizophrenia in the Chinese Han population

Abstract Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia p...

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Published in:Journal of psychiatric research 2010-04, Vol.44 (6), p.409-412
Main Authors: Zhang, Jing, Che, Ronglin, Li, Xingwang, Tang, Wei, Zhao, Qian, Tang, Ruqi, Wang, Yang, Zhang, Zhao, Ji, Jue, Yang, Fengping, Shi, Yongyong, Ji, Weidong, Zhou, Guoquan, Feng, Guoyin, He, Lin, He, Guang
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Association
Biological and medical sciences
China - epidemiology
Chinese Han population
Chinese people
Diagnostic and Statistical Manual of Mental Disorders
Female
FXYD6
Genes
Genetic Predisposition to Disease
Genotype
Humans
Ion Channels - genetics
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - genetics
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Summary:Abstract Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia patients and 1514 healthy controls. We also compared the expression levels of FXYD6 in lymphocytes in 86 schizophrenia patients and 94 controls. No association was detected either in D11S1998 or the 8 SNPs. No difference was found in expression level between patients and controls. Our study suggests that FXYD6 does not play a role in schizophrenia in the Chinese Han population.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2009.10.009