Two Novel and Anti-Inflammatory Constituents of Artocarpus rigida

With the scope of our search for biologically active compounds, two new phenolic compounds, artocarpols G (1) and H (2), and two known compounds, rubraflavone C (3) and trans‐stilbene‐2,4,3′,5′‐tetrol, were isolated from the root bark of Artocarpus rigida. Their structures were determined by spectro...

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Bibliographic Details
Published in:Helvetica chimica acta 2002-06, Vol.85 (6), p.1626-1632
Main Authors: Lu, Yi-Huang, Lin, Chun-Nan, Ko, Horng-Huey, Yang, Sheng-Zehn, Tsao, Lo-Ti, Wang, Jih-Pyang
Format: Article
Language:English
Subjects:
Artocarpus
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Summary:With the scope of our search for biologically active compounds, two new phenolic compounds, artocarpols G (1) and H (2), and two known compounds, rubraflavone C (3) and trans‐stilbene‐2,4,3′,5′‐tetrol, were isolated from the root bark of Artocarpus rigida. Their structures were determined by spectroscopic methods and comparison with data reported in the literature. Compound 4, previously isolated from this plant, strongly inhibited in a concentration‐dependent manner the release of β‐glucuronidase and histamine from mast cell degranulation caused by compound 48/80, with IC50 values of 10.9±1.4 and 13.2±0.6 μM, respectively. Compound 4 also showed a concentration‐dependent inhibitory effect on the formyl‐peptide‐stimulated superoxide anion formation in neutrophils with an IC50 value of 26.0±5.6 μM.
ISSN:0018-019X
1522-2675
DOI:10.1002/1522-2675(200206)85:6<1626::AID-HLCA1626>3.0.CO;2-0