Spinogenesis and Pruning from Early Visual Onset to Adulthood: An Intracellular Injection Study of Layer III Pyramidal Cells in the Ventral Visual Cortical Pathway of the Macaque Monkey

Neocortical pyramidal cells are characterized by markedly different structure among cortical areas in the mature brain. In the ventral visual pathway of adult primates, pyramidal cells become increasingly more branched and more spinous with anterior progression through the primary (V1), second (V2),...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2010-06, Vol.20 (6), p.1398-1408
Main Authors: Elston, Guy N., Oga, Tomofumi, Okamoto, Tsuguhisa, Fujita, Ichiro
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Cell Differentiation - physiology
Cell Shape - physiology
cortex
dendrite
Dendritic Spines - physiology
Dendritic Spines - ultrastructure
development
Hebbian rule
Macaca
Macaca fascicularis
Male
Neural Pathways - cytology
Neural Pathways - growth & development
Neural Pathways - physiology
Primates
Pyramidal Cells - cytology
Pyramidal Cells - physiology
spines
spontaneous activity
Temporal Lobe - cytology
Temporal Lobe - growth & development
Temporal Lobe - physiology
Visual Cortex - cytology
Visual Cortex - growth & development
Visual Cortex - physiology
Visual Pathways - cytology
Visual Pathways - growth & development
Visual Pathways - physiology
Visual Perception - physiology
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Summary:Neocortical pyramidal cells are characterized by markedly different structure among cortical areas in the mature brain. In the ventral visual pathway of adult primates, pyramidal cells become increasingly more branched and more spinous with anterior progression through the primary (V1), second (V2), and fourth (V4) visual areas and cytoarchitectonic areas TEO and TE. It is not known how these regional specializations in neuron structure develop. Here, we report that the basal dendritic trees of layer III pyramidal cells in V1, V2, V4, TEO, and TE were characterized by unique growth profiles. Different numbers of spines were grown in the dendritic trees of cells among these cortical areas and then subsequently pruned. In V1, V2, and V4, more spines were pruned than grew resulting in a net decrease in the number of spines in the dendritic trees following the onset of visual experience. In TEO and TE, neurons grew more spines than they pruned from visual onset to adulthood. These data suggest that visual experience may influence neuronal maturation in different ways in different cortical areas.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhp203