Lymphangiogenesis: Molecular Mechanisms and Future Promise

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired...

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Bibliographic Details
Published in:Cell 2010-02, Vol.140 (4), p.460-476
Main Authors: Tammela, Tuomas, Alitalo, Kari
Format: Article
Language:English
Subjects:
Animals
Endothelial Cells - physiology
Humans
Inflammation - physiopathology
Lymphangiogenesis - drug effects
Lymphatic Vessels - physiology
Lymphatic Vessels - physiopathology
Neoplasms - physiopathology
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Summary:The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2010.01.045