Lymphangiogenesis: Molecular Mechanisms and Future Promise

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired...

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Published in:Cell 2010-02, Vol.140 (4), p.460-476
Main Authors: Tammela, Tuomas, Alitalo, Kari
Format: Article
Language:English
Subjects:
Animals
Endothelial Cells - physiology
Humans
Inflammation - physiopathology
Lymphangiogenesis - drug effects
Lymphatic Vessels - physiology
Lymphatic Vessels - physiopathology
Neoplasms - physiopathology
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description The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.
doi_str_mv 10.1016/j.cell.2010.01.045
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source ScienceDirect®
subjects Animals
Endothelial Cells - physiology
Humans
Inflammation - physiopathology
Lymphangiogenesis - drug effects
Lymphatic Vessels - physiology
Lymphatic Vessels - physiopathology
Neoplasms - physiopathology
title Lymphangiogenesis: Molecular Mechanisms and Future Promise
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