Preparation and Biological Activity of Adrenoerythrin (? Adrenalinquinone)

IN the course of experiments carried out to study the inversion mechanism of adrenalin action on the uterus, I found, in 1945 1 , that when this hormone became oxidized (auto-oxidation in water made alkaline with sodium hydroxide) a red substance occasionally appeared, which preserved intact the hyp...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1950-11, Vol.166 (4228), p.831-832
Main Author: RUIZ-GIJON, J
Format: Article
Language:English
Subjects:
Epinephrine
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IN the course of experiments carried out to study the inversion mechanism of adrenalin action on the uterus, I found, in 1945 1 , that when this hormone became oxidized (auto-oxidation in water made alkaline with sodium hydroxide) a red substance occasionally appeared, which preserved intact the hypertensive action of adrenalin and, therefore, could not be the adrenochrome obtained by Green and Bichter in 1936. More recently, I have again had occasion to verify the existence of this substance, which I have called ‘adrenoerythrin’, and a paper is now in course of publication which confirms my previous findings 2 . Previously, I have not been able to obtain this substance systematically because of the large number of factors which influence the auto-oxidation of adrenalin. The object of the present communication is to describe a method by which it is possible to obtain the substance in question regularly, and to set forth some of its properties.
ISSN:0028-0836
1476-4687
DOI:10.1038/166831a0