Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L

The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1979, Vol.42 (1), p.103-111
Main Authors: Wat, Chi-kit, Biswas, R. K, Graham, E. A, Bohm, L, Towers, G. H. N, Waygood, E. R
Format: Article
Language:English
Subjects:
Alkynes - isolation & purification
Alkynes - metabolism
Alkynes - pharmacology
Animals
Anti-Bacterial Agents
Bacteria - drug effects
Bacteria - radiation effects
Cattle
Cell Survival - drug effects
Cell Survival - radiation effects
DNA - metabolism
Fibroblasts - drug effects
Fibroblasts - radiation effects
Fungi - drug effects
Fungi - radiation effects
Humans
Methoxsalen - pharmacology
Plants - analysis
Ultraviolet Rays
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Summary:The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in ultraviolet light.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50001a005