Post-extrasystolic left ventricular peak pressure with and without left ventricular failure

18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In ei...

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Bibliographic Details
Published in:Cardiovascular research 1979-06, Vol.13 (6), p.338-344
Main Authors: MERILLON, J. P., MOTTE, G., AUMONT, M. C., MASQUET, C., LECARPENTIER, Y., GOURGON, R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aorta - physiopathology
Blood Pressure
Cardiac Complexes, Premature - physiopathology
Compliance
Female
Heart Failure - physiopathology
Heart Ventricles - physiopathology
Hemodynamics
Humans
Male
Middle Aged
Myocardial Contraction
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Summary:18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In eight normal patients (group I), the post-extrasystolic peak pressure (P.ES.P.P.) was lower than that of the pre-extrasystolic beat; in 10 patients with symptoms of left ventricular failure (group II) the P.ES.P.P. significantly increased. The reasons are: 1) cardiac origin: stroke volume increased more in group II; 2) arterial origin. a) aortic compliance was lower in group II (this is probably related to the older age of patients in group II), and b) decrease in end-diastolic aortic pressure was smaller in group II. Part of this arterial effect (2b) may probably be explained from the fact that post-extrasystolic compensatory pauses are equal in both groups, but the decay time of arterial pressure during diastole (assuming an exponential decay) is larger in group II. At the same age and with the identical aortic compliance only the two factors 1 and 2b play a part in the changes in P.ES.P.P.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/13.6.338