B Cell Activating Properties of Parotid Protein

A new biological activity of bovine parotid protein acting on immunocompetent lymphocytes to lead to polyclonal antibody responses was demonstrated. A significant amount of antibody to SRBC or antihapten antibody to TNP-SRBC, BPO-SRBC, or SA-SRBC was produced in mice by adding the appropriate doses...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1979/06/20, Vol.23(6), pp.481-485
Main Authors: Ishizaka, Shigeaki, Morisawa, Seiji
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
B-Lymphocytes - immunology
Cattle
Clone Cells - immunology
Dose-Response Relationship, Immunologic
Hormones - pharmacology
Lymphocyte Activation
Mice
Mice, Inbred AKR
Mice, Inbred C3H
Parotid Gland
Salivary Proteins and Peptides - pharmacology
Spleen - immunology
T-Lymphocytes - immunology
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Summary:A new biological activity of bovine parotid protein acting on immunocompetent lymphocytes to lead to polyclonal antibody responses was demonstrated. A significant amount of antibody to SRBC or antihapten antibody to TNP-SRBC, BPO-SRBC, or SA-SRBC was produced in mice by adding the appropriate doses of bovine parotid protein, suggesting that this protein may be a nonspecific B cell activator which acts on the B cells in a similar way as casein or gelatin.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1979.tb00487.x