Infectious bursal disease viral infections. I. Complement and virus-neutralizing antibody response following infection of susceptible chickens

Complement (C) titers were decreased at 3 days postinfection, and virus-neutralizing (VN) antibody was detectable at 3 or 4 days postinfection in chickens with infectious bursal disease virus (IBDV). Clotting times were prolonged in all groups tested during the acute phase of the disease. Mortality...

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Bibliographic Details
Published in:Avian diseases 1979, Vol.23 (1), p.95-106
Main Authors: Skeeles, J. K., Lukert, P. D., De Buysscher, E. V., Fletcher, O. J., Brown, J.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral - analysis
Blood
Bursa of Fabricius - immunology
Bursa of Fabricius - microbiology
Chickens
Clotting
Complement System Proteins - metabolism
Hemorrhage
Infections
Infectious bursal disease virus
Infectious bursal disease virus - immunology
Infectious diseases
Memory interference
Poultry Diseases - immunology
Reoviridae - immunology
Viruses
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Summary:Complement (C) titers were decreased at 3 days postinfection, and virus-neutralizing (VN) antibody was detectable at 3 or 4 days postinfection in chickens with infectious bursal disease virus (IBDV). Clotting times were prolonged in all groups tested during the acute phase of the disease. Mortality appeared to be associated with the severity of decrease in C titer. The results suggest that the mortality and many of the clinical signs seen with infectious bursal disease are associated with: 1) a depletion in circulating levels of hemolytic C from the formation of immune complexes at sites of viral replication; and/or 2) a depletion in some clotting factor which results in hemorrhage.
ISSN:0005-2086
1938-4351
DOI:10.2307/1589676