Immunological characterization of mononuclear cells and morphological findings in patients with mammary carcinoma

Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be establis...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1979-09, Vol.95 (1), p.65-74
Main Authors: Heidenreich, W, Jagla, K, Schüssler, J, Börner, P, Dehnhard, F, Deinhardt, J, Kalden, J, Peter, H H, Deicher, H
Format: Article
Language:English
Subjects:
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Female
Humans
Immunity
Lymphatic Diseases - pathology
Lymphocytes - immunology
Lymphocytes - pathology
Prognosis
Receptors, Antigen, B-Cell
Rosette Formation
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Summary:Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be established to anyone of the following criteria for which the literature reports varying prognostic values: Clinical staging of the disease , histological tumor type, grading, nuclear differentiation, round cell infiltration, perivenous infiltration, sinus histiocytosis, and lymph node reaction patterns (lymphocyte predominance, germinal center predominance, lymphocyte depletion, unstimulated nodes). From the reported results it is concluded that the analysis of lymphocyte cell surface markers in mammary carcinoma is not a suitable parameter for supporting the existence of specific or unspecific anti-tumor immune reactions which may be suspected from certain histological reaction patterns.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00411111