Correlation between fragmented immunoglobulin genes and heavy chain deletion mutants

It is generally accepted that the variable (V) and constant (C) regions of immunoglobulin (Ig) chains are under separate genetic control 1 . The notion that the different domains and interdomain regions are also under the control of independent genetic units was initially based on the clearcut resul...

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Bibliographic Details
Published in:Nature (London) 1979-10, Vol.281 (5732), p.600-602
Main Authors: Frangione, Blas, Franklin, Edward C
Format: Article
Language:English
Subjects:
Base Sequence
Chromosome Deletion
Heavy Chain Disease - genetics
Humanities and Social Sciences
Humans
Immunoglobulin gamma-Chains - genetics
Immunoglobulin Heavy Chains - genetics
letter
Molecular Weight
multidisciplinary
Mutation
Nucleic Acid Precursors - genetics
Protein Conformation
RNA, Messenger - genetics
Science
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Summary:It is generally accepted that the variable (V) and constant (C) regions of immunoglobulin (Ig) chains are under separate genetic control 1 . The notion that the different domains and interdomain regions are also under the control of independent genetic units was initially based on the clearcut results obtained by studying the primary structure of deletion mutants 2–9 and received definitive support from direct analysis of cloned heavy (H) and light (L) chain genes 10–13 . Here we present additional studies carried out on two selected γ3 deletion mutants which indicate that the genetic control of human H chains may be even more complex than previously believed.
ISSN:0028-0836
1476-4687
DOI:10.1038/281600a0