Bupivacaine, 0.125 per cent, in obstetric epidural analgesia: experience in three thousand cases

Bupivacaine, 0.125 per cent, with epinephrine, 1:800,000, was administered to 3,000 women in labor. Administration was in the lumbar epidural space for the purpose of achieving satisfactory analgesia with minimal or no motor paralysis. The usual initial dose of 12.5 mg (mean 13 +/- 2 SD) resulted in...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1979-11, Vol.51 (5), p.435-438
Main Authors: Bleyaert, A, Soetens, M, Vaes, L, Van Steenberge, A L, Van der Donck, A
Format: Article
Language:English
Subjects:
Anesthesia, Epidural
Anesthesia, Obstetrical
Apgar Score
Bupivacaine - administration & dosage
Bupivacaine - pharmacology
Drug Combinations
Epinephrine - administration & dosage
Epinephrine - pharmacology
Female
Humans
Pregnancy
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Summary:Bupivacaine, 0.125 per cent, with epinephrine, 1:800,000, was administered to 3,000 women in labor. Administration was in the lumbar epidural space for the purpose of achieving satisfactory analgesia with minimal or no motor paralysis. The usual initial dose of 12.5 mg (mean 13 +/- 2 SD) resulted in good sensory analgesia in 83 per cent of the patients and lasted for about and hour (mean 58 +/- 16 min). The mean total dose used for labor and delivery was 55 +/- 20 mg and the mean dose per hour 23 +/- 13 mg. Satisfactory analgesia for labor and delivery was obtained in 92 per cent of the patients, and in 66 per cent there was no discernible motor blockade. In the 3,000 patients, there was no adverse reaction to bupivacaine or epinephrine. No patient had a total spinal block or neurologic sequelae, and no neonatal depression could be attributed to the anesthetic.
ISSN:0003-3022
DOI:10.1097/00000542-197911000-00013