Potential use of 1,25-dihydroxycholecalciferol for prevention of parturient paresis [Cows]

Twelve cows, at least third parity, were assigned randomly to either a control or treatment group. Treated cows received .4 mg of the vitamin D metabolite, 1,25-dihydroxycholecalciferol intramusculary in 5 ml corn oil. Intramuscular injections were started 5 days before predicted calving with reinje...

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Bibliographic Details
Published in:Journal of dairy science 1979-06, Vol.62 (6), p.1009-1013
Main Authors: Gast, D. R, Horst, R. L, Jorgensen, N. A, DeLuca, H. F
Format: Article
Language:English
Subjects:
Animals
Calcium - blood
Cattle
Dihydroxycholecalciferols - administration & dosage
Dihydroxycholecalciferols - blood
Dihydroxycholecalciferols - therapeutic use
Female
Hydroxycholecalciferols - therapeutic use
Injections, Intramuscular
Parturient Paresis - prevention & control
Phosphorus - blood
Pregnancy
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Summary:Twelve cows, at least third parity, were assigned randomly to either a control or treatment group. Treated cows received .4 mg of the vitamin D metabolite, 1,25-dihydroxycholecalciferol intramusculary in 5 ml corn oil. Intramuscular injections were started 5 days before predicted calving with reinjections every 5 days until calving. Incidence of parturient paresis was 0 and 33% (2 of 6) in the treated and control groups. Response to treatment was rapid with elevated calcium in serum approximately 12 h postinjection. Treatment maintained or elevated calcium and phosphorus concentrations in serum during the critical period, 24 h pre- to 48 h postpartum, when milk fever is most likely to occur. There was, however, no significant difference between treatments at 72 h postpartum. Based on these observations 1,25-dihydroxycholecalciferol holds promise as a preventative of parturient paresis; however, further studies are needed on application and safety.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.s0022-0302(79)83364-0