Effect of hypoxia on 67Ga incorporation into human granulocytes

Human granulocytes accumulate 67Ga when incubated under anoxic conditions and exclude the isotope when oxygenated. When incorporated, 67Ga is associated with the lysosomal fraction of the granulocytes. The ability of granulocytes to exclude the isotope except under hypoxic conditions may explain 67G...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1979-12, Vol.39 (12), p.4971-4974
Main Authors: Ostroy, F, Johnston, R B, Gams, R A
Format: Article
Language:English
Subjects:
Adult
Gallium Radioisotopes
Granulocytes - metabolism
Humans
Hypoxia
In Vitro Techniques
Inflammation - diagnostic imaging
Lymphocytes - metabolism
Neoplasms - diagnostic imaging
Oxygen
Radionuclide Imaging
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Summary:Human granulocytes accumulate 67Ga when incubated under anoxic conditions and exclude the isotope when oxygenated. When incorporated, 67Ga is associated with the lysosomal fraction of the granulocytes. The ability of granulocytes to exclude the isotope except under hypoxic conditions may explain 67Ga localization in abscesses and some tumor masses.
ISSN:0008-5472