Resolution of (±)‐Propranolol

Two improvements in propranolol resolution were developed. Both the (+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved....

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1979-09, Vol.68 (9), p.1181-1182
Main Authors: Yost, Yul, Holtzman, Jordan L.
Format: Article
Language:English
Subjects:
(+)- and (-)-di-(p-toluoyl)tartaric acids used as resolving agents
Crystallization
Enantiomers-propranolol
Enantiomers—propranolol, resolving agents
Propranolol - isolation & purification
Propranolol-racemic mixtures
Propranolol—racemic mixtures, resolution of enantiomers,.(+)‐ and (‐)‐di‐( p‐toluoyl)tartaric acids used as resolving agents
resolution of enantiomers
resolving agents
Stereoisomerism
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Description
Summary:Two improvements in propranolol resolution were developed. Both the (+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600680935