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Cell-mediated immunity in the liver of mice vaccinated against malaria
Mice can be protected against several species of lethal malaria infection by vaccination 1 , and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-ty...
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| Published in: | Nature (London) 1979-12, Vol.282 (5740), p.731-734 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c334t-853de17f60d5e181738fcbc1c129b8b71cf65fa13193f8e5315837964f8dbfbc3 |
| container_end_page | 734 |
| container_issue | 5740 |
| container_start_page | 731 |
| container_title | Nature (London) |
| container_volume | 282 |
| creator | Playfair, J. H. L De Souza, J. B Dockrell, H. M Agomo, P. U Taverne, J |
| description | Mice can be protected against several species of lethal malaria infection by vaccination
1
, and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin
3–5
, although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites
in vitro
to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction. |
| doi_str_mv | 10.1038/282731a0 |
| format | article |
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1
, and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin
3–5
, although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites
in vitro
to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/282731a0</identifier><identifier>PMID: 390399</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Cytotoxicity, Immunologic ; Humanities and Social Sciences ; Hypersensitivity, Delayed - immunology ; Immunity, Cellular ; letter ; Leukocytes - immunology ; Liver - immunology ; Malaria - immunology ; Malaria - prevention & control ; Mice ; multidisciplinary ; Plasmodium berghei - immunology ; Science ; Science (multidisciplinary) ; Spleen - immunology ; Vaccination</subject><ispartof>Nature (London), 1979-12, Vol.282 (5740), p.731-734</ispartof><rights>Springer Nature Limited 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-853de17f60d5e181738fcbc1c129b8b71cf65fa13193f8e5315837964f8dbfbc3</citedby><cites>FETCH-LOGICAL-c334t-853de17f60d5e181738fcbc1c129b8b71cf65fa13193f8e5315837964f8dbfbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2725,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/390399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Playfair, J. H. L</creatorcontrib><creatorcontrib>De Souza, J. B</creatorcontrib><creatorcontrib>Dockrell, H. M</creatorcontrib><creatorcontrib>Agomo, P. U</creatorcontrib><creatorcontrib>Taverne, J</creatorcontrib><title>Cell-mediated immunity in the liver of mice vaccinated against malaria</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Mice can be protected against several species of lethal malaria infection by vaccination
1
, and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin
3–5
, although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites
in vitro
to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction.</description><subject>Animals</subject><subject>Cytotoxicity, Immunologic</subject><subject>Humanities and Social Sciences</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunity, Cellular</subject><subject>letter</subject><subject>Leukocytes - immunology</subject><subject>Liver - immunology</subject><subject>Malaria - immunology</subject><subject>Malaria - prevention & control</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Plasmodium berghei - immunology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spleen - immunology</subject><subject>Vaccination</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNptkEtLAzEURoP4qlXwB4hkJboYTSYzk2QpxapQcKPrkMnc1JR51GSm0H9vdGpXru7iOxy4B6FLSu4pYeIhFSlnVJMDNKEZL5KsEPwQTQhJRUIEK07RWQgrQkhOeXaCjpkkTMoJms-grpMGKqd7qLBrmqF1_Ra7FvefgGu3AY87ixtnAG-0Ma79BfVSuzb0uNG19k6foyOr6wAXuztFH_On99lLsnh7fp09LhLDWNYnImcVUG4LUuVABeVMWFMaamgqS1FyamyRW00ZlcwKyBnNBeOyyKyoSlsaNkU3o3ftu68BQq8aF0x8QbfQDUHxjEtJhIzg7Qga34Xgwaq1d432W0WJ-imm_opF9GrnHMoYYg-OieJ8N84hDu0SvFp1g2_jl_-prkc2Rho87FV74Bt-6HxD</recordid><startdate>19791213</startdate><enddate>19791213</enddate><creator>Playfair, J. H. L</creator><creator>De Souza, J. B</creator><creator>Dockrell, H. M</creator><creator>Agomo, P. U</creator><creator>Taverne, J</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19791213</creationdate><title>Cell-mediated immunity in the liver of mice vaccinated against malaria</title><author>Playfair, J. H. L ; De Souza, J. B ; Dockrell, H. M ; Agomo, P. U ; Taverne, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-853de17f60d5e181738fcbc1c129b8b71cf65fa13193f8e5315837964f8dbfbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Cytotoxicity, Immunologic</topic><topic>Humanities and Social Sciences</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunity, Cellular</topic><topic>letter</topic><topic>Leukocytes - immunology</topic><topic>Liver - immunology</topic><topic>Malaria - immunology</topic><topic>Malaria - prevention & control</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Plasmodium berghei - immunology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spleen - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Playfair, J. H. L</creatorcontrib><creatorcontrib>De Souza, J. B</creatorcontrib><creatorcontrib>Dockrell, H. M</creatorcontrib><creatorcontrib>Agomo, P. U</creatorcontrib><creatorcontrib>Taverne, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Playfair, J. H. L</au><au>De Souza, J. B</au><au>Dockrell, H. M</au><au>Agomo, P. U</au><au>Taverne, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-mediated immunity in the liver of mice vaccinated against malaria</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1979-12-13</date><risdate>1979</risdate><volume>282</volume><issue>5740</issue><spage>731</spage><epage>734</epage><pages>731-734</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Mice can be protected against several species of lethal malaria infection by vaccination
1
, and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin
3–5
, although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites
in vitro
to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>390399</pmid><doi>10.1038/282731a0</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Cytotoxicity, Immunologic Humanities and Social Sciences Hypersensitivity, Delayed - immunology Immunity, Cellular letter Leukocytes - immunology Liver - immunology Malaria - immunology Malaria - prevention & control Mice multidisciplinary Plasmodium berghei - immunology Science Science (multidisciplinary) Spleen - immunology Vaccination |
| title | Cell-mediated immunity in the liver of mice vaccinated against malaria |
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