Antibacterial and Antifungal Activity of Benztropolone

FOLLOWING the suggestion of Dewar 1 , it is now generally accepted that the mould metabolic products, stipitatic acid, puberulic acid and puberulonic acid are derivatives of tropolone 2 . Erdtman and Gripenberg 3 have shown that α-, β- and γ-thujaplicins from Thuja plicata , the western red cedar tr...

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Bibliographic Details
Published in:Nature (London) 1950-07, Vol.166 (4210), p.65-65
Main Authors: BAILLIE, A. J, FREEMAN, G. G, COOK, J. W, SOMERVILLE, A. R
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Antifungal Agents
Fungicides, Industrial
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Tropolone
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Summary:FOLLOWING the suggestion of Dewar 1 , it is now generally accepted that the mould metabolic products, stipitatic acid, puberulic acid and puberulonic acid are derivatives of tropolone 2 . Erdtman and Gripenberg 3 have shown that α-, β- and γ-thujaplicins from Thuja plicata , the western red cedar tree, are, respectively, α-, β- and γ- iso propyltropolones. γ-Thujaplicin was found to possess fungicidal activity; when spores of Pullularia pullulans were suspended in a 0.02 per cent solution, 100 per cent survived after 1 hr., 11 per cent after 3 hr. and none after 6 hr. and 24 hr. exposure. Two of us (J. W. C. and A. R. S.) have recently described a synthesis of 3 : 4-benztropolone 4 .
ISSN:0028-0836
1476-4687
DOI:10.1038/166065a0