Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA

The hyper-modified nucleoside Q (queuosine) is exclusively located in the wobbling position of anticodons of tRNA Tyr , tRNA His , tRNA Asn and tRNA Asp that recognise codons NA c U (ref. 1). Queuosine and its hexose-containing derivatives 2,3 are widely distributed in microorganisms, animals and pl...

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Published in:Nature (London) 1979-11, Vol.282 (5734), p.107-109
Main Authors: Yokoyama, Shigeyuki, Miyazawa, Tatsuo, Iitaka, Yoichi, Yamaizumi, Ziro, Kasai, Hiroshi, Nishimura, Susumu
Format: Article
Language:English
Subjects:
Anticodon
Guanosine - analogs & derivatives
Humanities and Social Sciences
letter
Models, Molecular
multidisciplinary
Nucleic Acid Conformation
Nucleoside Q
Phenylalanine
RNA, Transfer
Saccharomyces cerevisiae
Science
Science (multidisciplinary)
Structure-Activity Relationship
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Summary:The hyper-modified nucleoside Q (queuosine) is exclusively located in the wobbling position of anticodons of tRNA Tyr , tRNA His , tRNA Asn and tRNA Asp that recognise codons NA c U (ref. 1). Queuosine and its hexose-containing derivatives 2,3 are widely distributed in microorganisms, animals and plants 4,5 . We confirm here the chemical structure of queuosine as 7-(3, 4- trans -4, 5- cis -dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine 2,6 (Fig. 1). The unique structural features of Q are the unusual cyclopentenediol side chain and the 7-deazaguanine ring. Queuosine is one of the most complicated modified nucleosides found thus far 7 .
ISSN:0028-0836
1476-4687
DOI:10.1038/282107a0