Action of alloxan on a hypoglycemic infant

A case report is presented of an eight month old white female who had a severe spontaneous hypoglycemia with associated convulsions. This condition was not appreciably improved with medical management and a subtotal pancreatectomy gave only temporary relief. The administration of alloxan monohydrate...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1951-05, Vol.7 (5), p.616-622
Main Authors: GRIFFITH, Jr, J E, JACKSON, R L, JANES, R G
Format: Article
Language:English
Subjects:
Alloxan
Blood Glucose
Hypoglycemic Agents
Infant
Old Medline
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Summary:A case report is presented of an eight month old white female who had a severe spontaneous hypoglycemia with associated convulsions. This condition was not appreciably improved with medical management and a subtotal pancreatectomy gave only temporary relief. The administration of alloxan monohydrate caused a cessation of convulsions, elevated the blood sugar and improved the glucose tolerance. The response noted in this child with alloxan therapy indicates that the initial dose should be approximately 55 mg/kg. body weight given by rapid intravenous injection. The dose should be increased by 5 mg./kg. body weight daily until a mild hyperglycemia is produced. Fourteen months after the last injection of alloxan the child had remained free of convulsions and her social developmental age was considered to be within normal limits. Blood sugar values obtained during the 14 month interval were improved over the pre-alloxan picture. However, values below the normal fasting level have been observed.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.7.5.616