Serial Hemodynamic Studies During the Treatment of Congestive Heart Failure With Isolated Low-Dose Oral Prazosin Therapy

Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitori...

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Bibliographic Details
Published in:Angiology 1979-12, Vol.30 (12), p.850-855
Main Authors: Reyns, Philippe, Romney, David, Desser, Kenneth B., Benchimol, Alberto
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Female
Heart Failure - drug therapy
Hemodynamics - drug effects
Humans
Male
Middle Aged
Prazosin - administration & dosage
Prazosin - pharmacology
Quinazolines - administration & dosage
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Summary:Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitoring in dicated a significant reduction of preload and afterload with a concomitant rise in the cardiac index. We concluded that isolated low-dose oral prazosin has salutary effects on indices of hemodynamic function in selected patients.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331977903001209