Novel One-Pot Method for Chemoselective Bromination and Sequential Sonogashira Coupling

An efficient one-pot method for bromination−elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalkanes having an adjacent O-functional group.

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Bibliographic Details
Published in:Organic letters 2010-08, Vol.12 (15), p.3316-3319
Main Authors: Kutsumura, Noriki, Niwa, Kentaro, Saito, Takao
Format: Article
Language:English
Subjects:
Catalysis
Combinatorial Chemistry Techniques
Halogenation
Molecular Structure
Propanols - chemistry
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Summary:An efficient one-pot method for bromination−elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalkanes having an adjacent O-functional group.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101110v