Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1)

• Published in: Respiratory medicine 2010-09, Vol.104 (9), p.1254-1262
• Main Authors: Broekema, M, Volbeda, F, Timens, W, Dijkstra, A, Lee, N A, Lee, J J, Lodewijk, M E, Postma, D S, Hylkema, M N, ten Hacken, N H T
• Format: Article
• Language: English
• Subjects: Adult; Aged; Airway Remodeling - physiology; Asthma - pathology; Asthma - physiopathology; Bronchoscopy; Disease Progression; Eosinophilia - pathology; Eosinophilia - physiopathology; Eosinophils - pathology; Female; Forced Expiratory Volume - physiology; Humans; Inflammation Mediators - metabolism; Male; Middle Aged; Remission, Spontaneous; Sputum - cytology; Sputum - metabolism
• ISSN: 1532-3064
• DOI: 10.1016/j.rmed.2010.03.030

As it is unknown whether complete asthma remission or progression of asthma is associated with airway inflammation and remodeling, we assessed these characteristics in bronchial biopsies of relevant subsets of asthma patients. Sputum and bronchial biopsies were obtained from asthma patients in remission (PC(20) histamine> 32 mg/ml, PC(20) AMP> 320 mg/ml) and from those with either a slow FEV(1) decline (< 30 ml/year) or fast decline (> 30 ml/year). Inflammatory cells and mediators were determined in sputum, inflammatory cells and aspects of airway remodeling in bronchial biopsies. Asthmatics in remission and asthma patients with a slow FEV(1) decline had a similar extent of airway inflammation and remodeling in sputum and bronchial biopsies. Asthma patients with a fast FEV(1) decline had high sputum eosinophil numbers. Moreover, FEV(1) decline (ml/year) correlated with sputum eosinophil numbers (Rs=0.51, p=0.003) and ECP levels (Rs=0.57, p=0.001). Airway remodeling, i.e. basement membrane thickness, correlated with sputum eosinophils (Rs=0.69, p