Iron deficiency: an ominous sign in patients with systolic chronic heart failure

Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to exami...

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Bibliographic Details
Published in:European heart journal 2010-08, Vol.31 (15), p.1872-1880
Main Authors: Jankowska, Ewa A., Rozentryt, Piotr, Witkowska, Agnieszka, Nowak, Jolanta, Hartmann, Oliver, Ponikowska, Beata, Borodulin-Nadzieja, Ludmila, Banasiak, Waldemar, Polonski, Lech, Filippatos, Gerasimos, McMurray, John J.V., Anker, Stefan D., Ponikowski, Piotr
Format: Article
Language:English
Subjects:
Aged
Anemias. Hemoglobinopathies
Biological and medical sciences
C-Reactive Protein - metabolism
Cardiology. Vascular system
Chronic Disease
Chronic heart failure
Disease-Free Survival
Diseases of red blood cells
Female
Ferritins - blood
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart Failure, Systolic - complications
Heart Failure, Systolic - metabolism
Hematologic and hematopoietic diseases
Humans
Iron - deficiency
Kaplan-Meier Estimate
Male
Medical sciences
Metabolic diseases
Metals (hemochromatosis...)
Middle Aged
Natriuretic Peptide, Brain - metabolism
Other metabolic disorders
Peptide Fragments - metabolism
Prognosis
Prospective Studies
Survival
Transferrin - metabolism
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Summary:Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to examine the relationship between ID and survival in patients with systolic CHF. Methods and results In a prospective observational study, we evaluated 546 patients with stable systolic CHF [age: 55 ± 11 (mean ± standard deviation) years, males: 88%, left ventricular ejection fraction: 26 ± 7%, New York Heart Association (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: ferritin
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehq158