Effects of hemorrhagic hypotension on the cerebral circulation. II. Electrocortical function

The effects of graded hemorrhagic hypotension on electrocortical function was investigated in 12 cats anesthetized with alpha-chloralose. Cerebral function was assessed both in terms of spontaneous activity (EEG) and the somatosensory evoked response. No significant changes in the EEG trace or in th...

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Bibliographic Details
Published in:Stroke (1970) 1979-11, Vol.10 (6), p.719-723
Main Authors: Gregory, P C, McGeorge, A P, Fitch, W, Graham, D I, MacKenzie, E T, Harper, A M
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Cats
Cerebrovascular Circulation
Electroencephalography
Evoked Potentials
Female
Male
Shock, Hemorrhagic - physiopathology
Somatosensory Cortex - physiopathology
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Summary:The effects of graded hemorrhagic hypotension on electrocortical function was investigated in 12 cats anesthetized with alpha-chloralose. Cerebral function was assessed both in terms of spontaneous activity (EEG) and the somatosensory evoked response. No significant changes in the EEG trace or in the amplitude of the positive/negative waves of the primary evoked response were observed at mean arterial pressures of between 120 mm Hg and 40 mm Hg. At levels of systemic arterial pressure of less than 40 mm Hg cortical rhythms became slower as pressure was decreased and an isoelectric EEG was recorded in the pressure range 10--30 mm Hg. The earliest sign of any change in the amplitude of the primary evoked responses was observed at arterial pressures of approximately 35--40 mm Hg. Below this value the amplitude decreased with decreasing systemic pressure and became zero in the pressure range 15--25 mm Hg.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.10.6.719