The role of kisspeptin signaling in reproduction

Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of dif...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2010-08, Vol.25 (4), p.207-217
Main Authors: d'Anglemont de Tassigny, Xavier, Colledge, William Henry
Format: Article
Language:English
Subjects:
Animals
Gonadotropin-Releasing Hormone - genetics
Gonadotropin-Releasing Hormone - physiology
Humans
Kisspeptins
Neurons - physiology
Proteins - genetics
Rats
Reproduction - genetics
Reproduction - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Tumor Suppressor Proteins - agonists
Tumor Suppressor Proteins - antagonists & inhibitors
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - physiology
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Description
Summary:Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00009.2010