Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 dia...

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Bibliographic Details
Published in:Diabetes & vascular disease research 2010-07, Vol.7 (3), p.213-215
Main Authors: Nassimizadeh, Mohammad, Ashrafian, Houman, Drury, Nigel E, Howell, Neil J, Digby, Janet, Pagano, Domenico, Frenneaux, Michael P, Born, Gustav VR
Format: Article
Language:English
Subjects:
Case-Control Studies
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Diabetic Angiopathies - etiology
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - pathology
Endothelium, Vascular - chemistry
Endothelium, Vascular - ultrastructure
Ferritins
Glycocalyx - metabolism
Humans
Mammary Arteries - chemistry
Mammary Arteries - ultrastructure
Microscopy, Electron
N-Acetylneuraminic Acid - blood
Staining and Labeling - methods
Surface Properties
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Summary:Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.
ISSN:1479-1641
1752-8984
DOI:10.1177/1479164110376207