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Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 dia...

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Published in:	Diabetes & vascular disease research 2010-07, Vol.7 (3), p.213-215
Main Authors:	Nassimizadeh, Mohammad, Ashrafian, Houman, Drury, Nigel E, Howell, Neil J, Digby, Janet, Pagano, Domenico, Frenneaux, Michael P, Born, Gustav VR
Format:	Article
Language:	English
Subjects:	Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetic Angiopathies - etiology Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Endothelium, Vascular - chemistry Endothelium, Vascular - ultrastructure Ferritins Glycocalyx - metabolism Humans Mammary Arteries - chemistry Mammary Arteries - ultrastructure Microscopy, Electron N-Acetylneuraminic Acid - blood Staining and Labeling - methods Surface Properties
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description	Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.
doi_str_mv	10.1177/1479164110376207
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subjects	Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetic Angiopathies - etiology Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Endothelium, Vascular - chemistry Endothelium, Vascular - ultrastructure Ferritins Glycocalyx - metabolism Humans Mammary Arteries - chemistry Mammary Arteries - ultrastructure Microscopy, Electron N-Acetylneuraminic Acid - blood Staining and Labeling - methods Surface Properties
title	Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients
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