Preoperative [18F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer

Purpose To determine if preoperative [ 18 F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer. Methods Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standard...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2010-08, Vol.37 (8), p.1467-1473
Main Authors: Chung, Hyun Hoon, Nam, Byung-Ho, Kim, Jae Weon, Kang, Keon Wook, Park, Noh-Hyun, Song, Yong-Sang, Chung, June-Key, Kang, Soon-Beom
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological Transport
Cardiology
Cervical cancer
Clinical outcomes
Female
Fluorodeoxyglucose F18 - metabolism
Humans
Imaging
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Oncology
Original Article
Orthopedics
Positron-Emission Tomography
Preoperative Period
Prognosis
Radiology
Recurrence
Retrospective Studies
Surgery
Tomography
Tomography, X-Ray Computed
Tumors
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - surgery
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To determine if preoperative [ 18 F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer. Methods Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standardized uptake value (SUV max ) of FDG in the primary tumour during PET/CT and recurrence was examined. Results Included in the study were 75 patients. Medical records including clinical data, treatment modalities, and treatment results were retrospectively reviewed. The median duration of follow-up was 13 months (range 3 to 58 months) after treatment. Median preoperative SUV max values in the primary tumours were significantly higher in patients with higher FIGO stages ( p  = 0.0149), pelvic lymph node metastasis ( p  = 0.0068), parametrial involvement ( p  = 0.0002), large (>4 cm) tumour size ( p  = 0.0022), presence of lymphovascular space invasion ( p  = 0.0055), and deep cervical stromal invasion ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-010-1413-5