Simultaneous Determination of Albendazole and Praziquantel by Second Derivative Spectrophotometry and Multivariated Calibration Methods in Veterinary Pharmaceutical Formulation

The simultaneous determination of albendazole (ABZ) and praziquantel (PZQ) was performed by different mathematical approaches: second derivative spectrophotometry (SDS), classical least squares, regression of partial least squares and principal components regression based on spectral data of drugs d...

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Bibliographic Details
Published in:Analytical Sciences 2010/08/10, Vol.26(8), pp.891-896
Main Authors: SOTO, César, CONTRERAS, David, ORELLANA, Sandra, YAÑEZ, Jorge, TORAL, M. Inés
Format: Article
Language:English
Subjects:
Albendazole - analysis
Analytical Chemistry
Animals
Chemistry
Hydrochloric Acid
Least-Squares Analysis
Limit of Detection
Methanol
Multivariate Analysis
Original Papers
Pharmaceutical Preparations - analysis
Praziquantel - analysis
Spectrophotometry - methods
Veterinary Drugs - analysis
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Summary:The simultaneous determination of albendazole (ABZ) and praziquantel (PZQ) was performed by different mathematical approaches: second derivative spectrophotometry (SDS), classical least squares, regression of partial least squares and principal components regression based on spectral data of drugs dissolved in methanol-hydrochloric acid solution. The detection limits for multivariate calibrations were determined by creating a surrogate variable signal. SDS presented the best analytical features. The recoveries of ABZ and PZQ from the synthetic samples were near to 100 ± 5%. The methods were applied in veterinary pharmaceutical formulation whose mass ratio ABZ:PZQ is 10:1; the results obtained were according to nominal content.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.26.891