Estrogen Receptors α and β Immunohistochemical Expression: Clinicopathological Correlations in Pituitary Adenomas

We investigated the immunohistochemical expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in pituitary adenoma subtypes combined with clinicopathological factors. Pituitary adenomas (n=75) were immunostained for ERalpha and ERbeta using the streptavidin-biotin-peroxidase complex met...

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Bibliographic Details
Published in:Anticancer research 2010-07, Vol.30 (7), p.2897-2904
Main Authors: MANORANJAN, B, SALEHI, F, SCHEITHAUER, B. W, ROTONDO, F, KOVACS, K, CUSIMANO, M. D
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Biological and medical sciences
Cell Nucleus - metabolism
Cytoplasm - metabolism
Endocrinopathies
Estrogen Receptor alpha - biosynthesis
Estrogen Receptor alpha - metabolism
Estrogen Receptor beta - biosynthesis
Estrogen Receptor beta - metabolism
Female
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Immunohistochemistry
Male
Medical sciences
Neoplasm Invasiveness
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Tumors
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Summary:We investigated the immunohistochemical expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in pituitary adenoma subtypes combined with clinicopathological factors. Pituitary adenomas (n=75) were immunostained for ERalpha and ERbeta using the streptavidin-biotin-peroxidase complex method with a monoclonal ERalpha antibody and polyclonal ERbeta antibody. Nuclear immunoreactivity for both receptors was highest among PRL, FSH/LH, null cell, and GH adenomas. ACTH, silent subtypes I and II corticotrophs, and subtype III adenomas were the least immunoreactive for both receptors. ACTH adenomas expressed significantly less ERalpha than FSH-LH, GH, and null cell adenomas. A significantly elevated ERalpha expression was observed in macroadenomas compared to microadenomas and non-invasive compared to invasive tumors. ERalpha and ERbeta are differentially expressed in the various pituitary adenoma subtypes suggesting a cell-specific function for these receptors. To elucidate the role of ERalpha in tumor size and invasiveness, additional studies are required.
ISSN:0250-7005
1791-7530