CCND1 and CDKN1B Polymorphisms and Risk of Breast Cancer

• Published in: Anticancer research 2010-07, Vol.30 (7), p.3093-3098
• Main Authors: CANBAY, Emel, ERALTAN, Ilhan Yaylim, UNAL, Hilal, CERCEL, Ali, ISBIR, Turgay, GAZIOGLU, Ertugrul, AYDOGAN, Fatih, CACINA, Canan, CENGIZ, Ali, FERAHMAN, Mehmet, ZENGIN, Emel
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alleles; Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cyclin D1 - genetics; Cyclin-Dependent Kinase Inhibitor p27; Female; Genetic Predisposition to Disease; Genotype; Gynecology. Andrology. Obstetrics; Humans; Intracellular Signaling Peptides and Proteins - genetics; Mammary gland diseases; Medical sciences; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Tumors
• ISSN: 0250-7005; 1791-7530

Previous studies have shown alterations in the cell cycle regulatory proteins in breast carcinomas. However, the results of these studies remain controversial. Cyclin D1 (CCND1) and p27(KIP1) (CDKN1B) are two essential regulators of cell cycle progression. This study aimed to investigate the associations of CCND1 A870G and CDKN1B C79T polymorphisms with breast cancer risk. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotype and allelic frequencies of polymorphisms. Seventy-eight breast cancer patients and 84 age-matched healthy controls were included in the study. Frequencies of CT genotype and T allele of CDKN1B were found to be higher in breast cancer patients than in controls (p=0.013, OR: 1.514 95% CI: 1.086-2.114.15; p=0.007, OR=1.496; 95% CI: 1.111-2.014, respectively). The frequency of AA genotype of CCND1 was decreased in hormone receptor- (estrogen and progesterone receptors) negative patients with breast cancer (p