Gas Chromatography-Combustion-Mass Spectrometry with Postcolumn Isotope Dilution for Compound-Independent Quantification: Its Potential to Assess HS-SPME Procedures

A quadrupole GC-MS instrument with an electron ionization (EI) source has been modified to enable application of postcolumn isotope dilution analysis for the standardless quantification of organic compounds injected in the gas chromatograph. Instrumental modifications included the quantitative conve...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2010-08, Vol.82 (16), p.6862-6869
Main Authors: Díaz, Sergio Cueto, Encinar, Jorge Ruiz, Sanz-Medel, Alfredo, García Alonso, J. Ignacio
Format: Article
Language:English
Subjects:
Analytical chemistry
Carbon dioxide
Chemical compounds
Chromatography
Isotopes
Mass spectrometry
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Summary:A quadrupole GC-MS instrument with an electron ionization (EI) source has been modified to enable application of postcolumn isotope dilution analysis for the standardless quantification of organic compounds injected in the gas chromatograph. Instrumental modifications included the quantitative conversion of the separated compounds into CO2, using a postcolumn combustion furnace, and the subsequent mixing of the gas with a constant flow of 13CO2 diluted in helium. The online measurement of the 12CO2/13CO2 (44/45) ratio in the EI-MS allowed us to obtain quantitative data without resorting to compound-specific standards. Validation of the procedure involved the analysis of standard solutions containing different families of organic compounds (C9−C20 linear hydrocarbons, BTEX and esters) obtaining satisfactory results in all cases in terms of absolute errors (
ISSN:0003-2700
1520-6882
DOI:10.1021/ac101103n