Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus

Neuropeptide Y （NPY） is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine eouopeptides （designated as cono-NPYs） were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs,...

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Bibliographic Details
Published in:Acta biochimica et biophysica Sinica 2010-07, Vol.42 (7), p.502-505
Main Authors: Wu, Xuechen, Shao, Xiaoxia, Guo, Zhan-Yun, Chi, Cheng-Wu
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Chromatography, High Pressure Liquid
Conus Snail - chemistry
Conus Snail - genetics
Dose-Response Relationship, Drug
Evolution, Molecular
Hyperkinesis - physiopathology
Injections, Intraventricular
Mice
Molecular Sequence Data
Molecular Weight
Mollusk Venoms - chemistry
Neuropeptide Y - genetics
Neuropeptide Y - isolation & purification
Neuropeptide Y - pharmacology
Peptide Fragments - analysis
Sequence Homology, Amino Acid
无脊椎动物
神经肽Y
进化过程
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Summary:Neuropeptide Y （NPY） is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine eouopeptides （designated as cono-NPYs） were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.
ISSN:1672-9145
1745-7270
DOI:10.1093/abbs/gmq042