Nortriterpene Lactones from the Fruits of Schisandra arisanensis

Fractionation of an acetone extract from the fruits of Schisandra arisanensis afforded five new nortriterpene lactones, compounds 1−5, together with four known compounds, schindilactones D and E (6 and 7) and preschisanartanins A and B (8 and 9). Compound 1, a wuweiziartane-type nortriterpenoid, pos...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-07, Vol.73 (7), p.1228-1233
Main Authors: Cheng, Yuan-Bin, Liao, Tzu-Ching, Lo, Yi-Wen, Chen, Yu-Chen, Kuo, Yuh-Chi, Chen, Shun-Ying, Chien, Ching-Te, Hwang, Tsong-Long, Shen, Ya-Ching
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Biological and medical sciences
Crystallography, X-Ray
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Fruit - chemistry
General pharmacology
Herpesvirus 1, Human - drug effects
Humans
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Molecular Conformation
Molecular Structure
Neutrophils - drug effects
Neutrophils - enzymology
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Schisandra - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fractionation of an acetone extract from the fruits of Schisandra arisanensis afforded five new nortriterpene lactones, compounds 1−5, together with four known compounds, schindilactones D and E (6 and 7) and preschisanartanins A and B (8 and 9). Compound 1, a wuweiziartane-type nortriterpenoid, possesses a new type of fused ring system with a γ-lactone ring between C-15 and C-17. Compounds 2, 6, and 7 may be categorized as schisanartane-type nortriterpenoids and compounds 3−5, 8, and 9 as preschisanartane-type nortriterpenoids. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data interpretation. The structure and relative configuration of 3 were supported by single-crystal X-ray diffraction analysis. The antiviral activity against HSV-1 and inhibitory effects on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB of compounds 1−9 were evaluated.
ISSN:0163-3864
1520-6025
DOI:10.1021/np100048h