MAD2 downregulation in hypoxia is independent of promoter hypermethylation

Aberrant expression of the MAD2 protein has been linked to chromosomal instability, malignant transformation and chemoresistance. Although reduced MAD2 expression is well recognised in human cancer cell lines, the mechanism(s) underlying its down-regulation remain elusive.

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2010-07, Vol.9 (14), p.2928-2937
Main Authors: Prencipe, Maria, McGoldrick, Aloysius, Perry, Antoinette S, O'Grady, Anthony, Phelan, Sine, McGrogan, Barbara, Fitzpatrick, Patricia, Watson, Jenny A, Furlong, Fiona, Brennan, Donal J, Lawler, Mark, Kay, Elaine, McCann, Amanda
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - metabolism
Azacitidine - analogs & derivatives
Azacitidine - pharmacology
Binding
Biology
Bioscience
Calcium
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - metabolism
Calcium-Binding Proteins - physiology
Cancer
Carbonic Anhydrase IX
Carbonic Anhydrases - metabolism
Cell
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Cycle Proteins - physiology
Cell Hypoxia
Cell Line, Tumor
Cycle
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
DNA Methylation
Down-Regulation
Humans
Landes
Mad2 Proteins
Organogenesis
Promoter Regions, Genetic
Proteins
Repressor Proteins - genetics
Repressor Proteins - metabolism
Repressor Proteins - physiology
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Description
Summary:Aberrant expression of the MAD2 protein has been linked to chromosomal instability, malignant transformation and chemoresistance. Although reduced MAD2 expression is well recognised in human cancer cell lines, the mechanism(s) underlying its down-regulation remain elusive.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.9.14.12362