Structures of DNA Polymerases Caught Processing Size-Augmented Nucleotide Probes

The right fit: Synthetic nucleotide analogues are widely used to investigate the mechanisms that govern DNA polymerase selectivity—processes that are crucial for the survival of every living organism. The first crystal structures of size‐augmented 4′‐methylated and 4′‐ethylated thymidine triphosphat...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-07, Vol.49 (30), p.5181-5184
Main Authors: Betz, Karin, Streckenbach, Frank, Schnur, Andreas, Exner, Thomas, Welte, Wolfram, Diederichs, Kay, Marx, Andreas
Format: Article
Language:English
Subjects:
DNA
DNA polymerase
DNA Probes - chemistry
DNA replication
DNA-Directed DNA Polymerase - chemistry
DNA-Directed DNA Polymerase - genetics
Kinetics
Models, Molecular
Mutation
nucleotides
Protein Structure, Tertiary
structure elucidation
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Summary:The right fit: Synthetic nucleotide analogues are widely used to investigate the mechanisms that govern DNA polymerase selectivity—processes that are crucial for the survival of every living organism. The first crystal structures of size‐augmented 4′‐methylated and 4′‐ethylated thymidine triphosphates (TTPs) in complex with a DNA polymerase have been elucidated (picture: superposition of three DNA polymerase structures in complex with TTPs).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200905724