Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension

Preeclampsia is a life-threatening pregnancy syndrome of uncertain origin. To elucidate the pathogenesis, we evaluated the temporal relationships between changes in vascular function and circulating biomarkers of angiogenic activity before and after the onset of preeclampsia and gestational hyperten...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2010-08, Vol.122 (5), p.478-487
Main Authors: Noori, Muna, Donald, Ann E, Angelakopoulou, Aspasia, Hingorani, Aroon D, Williams, David J
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - blood
Biomarkers - blood
Blood Pressure - physiology
Brachial Artery - physiology
Endoglin
Female
Humans
Hypertension, Pregnancy-Induced - blood
Hypertension, Pregnancy-Induced - epidemiology
Neovascularization, Physiologic - physiology
Placenta Growth Factor
Pre-Eclampsia - blood
Pre-Eclampsia - epidemiology
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Proteins - blood
Prospective Studies
Pulsatile Flow - physiology
Receptors, Cell Surface - blood
Risk Factors
Uterine Artery - physiology
Vascular Endothelial Growth Factor Receptor-1 - blood
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Summary:Preeclampsia is a life-threatening pregnancy syndrome of uncertain origin. To elucidate the pathogenesis, we evaluated the temporal relationships between changes in vascular function and circulating biomarkers of angiogenic activity before and after the onset of preeclampsia and gestational hypertension. Maternal mean arterial pressure, uterine artery pulsatility index, brachial artery flow-mediated dilatation, and serum concentrations of placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and soluble endoglin were prospectively measured in 159 women from 10 weeks gestation until 12 weeks postpartum. At 10 to 17 weeks, women who developed preterm preeclampsia had lower serum PlGF (P=0.003), higher soluble endoglin (P=0.006), and higher sFlt-1:PlGF ratio (P=0.005) compared with women who later developed term preeclampsia, gestational hypertension, or normotensive pregnancy. At 10 to 17 weeks, mean arterial pressure inversely correlated with serum PlGF (r=-0.19, P=0.02); at 18 to 25 weeks, with soluble endoglin (r=0.18, P=0.02); and at 26 to 33 weeks, with sFlt-1 (r=0.28, P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.109.895458