New pyrazoline derivatives and their antidepressant activity

Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB +-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2010-09, Vol.45 (9), p.4383-4387
Main Authors: Kaplancıklı, Zafer Asım, Özdemir, Ahmet, Turan-Zitouni, Gülhan, Altıntop, Mehlika Dilek, Can, Özgür Devrim
Format: Article
Language:English
Subjects:
Animals
Antidepressant activity
Antidepressive Agents - chemical synthesis
Antidepressive Agents - chemistry
Antidepressive Agents - pharmacology
Behavior, Animal - drug effects
Biological and medical sciences
Male
Medical sciences
Mice
Modified forced swimming test
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyrazoline
Rota-Rod
Tail suspension tests
Triazole
Triazoles - chemistry
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Summary:Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB +-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities. The study supports the antidepressant-like activities of various pyrazoline and/or triazole derivatives and suggests a possible serotonin related mechanism of action for the tested compounds. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2010.06.011