Systemic inflammation following non-surgical and surgical periodontal therapy

• Published in: Journal of clinical periodontology 2010-09, Vol.37 (9), p.848-854
• Main Authors: Graziani, Filippo, Cei, Silvia, Tonetti, Maurizio, Paolantonio, Michele, Serio, Rossella, Sammartino, Gilberto, Gabriele, Mario, D'Aiuto, Francesco
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biomarkers - blood; Blood Pressure - physiology; C reactive protein; C-Reactive Protein - analysis; Chronic Periodontitis - blood; Chronic Periodontitis - surgery; Chronic Periodontitis - therapy; Cohort Studies; cystatin C; Cystatin C - blood; Dental Plaque - prevention & control; Dental Scaling; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Fibrin Fibrinogen Degradation Products - analysis; Follow-Up Studies; Gingival Hemorrhage - surgery; Gingival Hemorrhage - therapy; Gingival Recession - surgery; Gingival Recession - therapy; Humans; Inflammation; Inflammation Mediators - blood; Leukocyte Count; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; Periodontal Attachment Loss - surgery; Periodontal Attachment Loss - therapy; periodontal disease; Periodontal Pocket - surgery; Periodontal Pocket - therapy; periodontal surgery; Root Planing; Serum Amyloid A Protein - analysis; systemic inflammation; Time Factors
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/j.1600-051X.2010.01585.x

Graziani F, Cei S, Tonetti M, Paolantonio M, Serio R, Sammartino G, Gabriele M, D'Aiuto F. Systemic inflammation following non‐surgical and surgical periodontal therapy. J Clin Periodontol 2010; 37: 848–854. doi: 10.1111/j.1600‐051X.2010.01585.x. Aim: To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non‐surgical treatment of chronic periodontitis (CP). Material and Methods: Fourteen CP cases received full‐mouth non‐surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time‐points after treatment. Blood markers of systemic inflammation/coagulation including leucocyte counts, C‐reactive protein (CRP), serum amyloid‐A (SAA) and D‐dimers and renal function (cystatin C) were determined using high‐sensitivity assays. Results: Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non‐surgical therapy (p