Comparing the in vivo glycine fluxes of adolescent girls and adult women during early and late pregnancy

During pregnancy, growth of the foetus depends on an adequate glycine supply because it is needed for synthesis of fetal DNA, collagen and serine. Since pregnant adolescent girls give birth to lower birth weight babies, it is possible that they do not produce sufficient glycine to meet overall deman...

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Bibliographic Details
Published in:British journal of nutrition 2010-08, Vol.104 (4), p.498-502
Main Authors: Thame, Minerva, Fletcher, Horace, Baker, Tameka, Jahoor, Farook
Format: Article
Language:English
Subjects:
Adolescent
Adolescent pregnancy
Adolescents
Adult
age differences
Age Factors
Amino acids
Biological and medical sciences
birth weight
blood chemistry
collagen
Comparative studies
DNA
early pregnancy
embryogenesis
fasting
Fasting - physiology
Feeding. Feeding behavior
Female
fetal development
Fetal Growth Retardation - etiology
First trimester
Fluctuations
food intake
Fundamental and applied biological sciences. Psychology
glycine (amino acid)
Glycine - administration & dosage
Glycine - blood
Glycine flux
Humans
Infusions, Intravenous
late pregnancy
Low birth weight
Pregnancy
Pregnancy - blood
Pregnancy Trimester, First
Pregnancy Trimester, Third
pregnant adolescents
pregnant women
Prenatal development
serine
Teenagers
temporal variation
Third trimester
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Women
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Summary:During pregnancy, growth of the foetus depends on an adequate glycine supply because it is needed for synthesis of fetal DNA, collagen and serine. Since pregnant adolescent girls give birth to lower birth weight babies, it is possible that they do not produce sufficient glycine to meet overall demands as their adult counterparts, especially after an overnight fast. The objective of the study was to measure and compare the flux of glycine among adolescents and adult women in the first and third trimesters of pregnancy. Glycine flux was measured by continuous intravenous infusion of 2H2-glycine in eight overnight fasted adolescents and in eight adult women in the first and third trimesters of pregnancy. There was a significant interaction between subject's age and time of pregnancy (P = 0·02), as weight-specific glycine flux decreased by 39 % from trimesters 1 to 3 in the adolescents but increased by approximately 5 % in the adults. Whole body glycine flux also decreased significantly in the adolescent group (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114510000784