Inheritance patterns, consanguinity & risk for asthma

Family history is an important risk factor for the development of asthma, contingent upon genetic and environment interaction. Since there is paucity of data on asthma inheritance in Indian population, the present study was undertaken to investigate the inheritance patterns of asthma and the effect...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2010-07, Vol.132 (1), p.48-55
Main Authors: Mahdi, Bijanzadeh, Mahesh, P A, Mysore, R Savitha, Kumar, Pradeep, Jayaraj, B S, Ramachandra, Nallur B
Format: Article
Language:English
Subjects:
Adult
Asthma
Asthma - epidemiology
Asthma - genetics
Case-Control Studies
Child
Consanguinity
Demography
Diagnosis
Female
Genetic aspects
Humans
India - epidemiology
Inheritance Patterns - genetics
Male
Pedigree
Risk Factors
Surveys and Questionnaires
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Summary:Family history is an important risk factor for the development of asthma, contingent upon genetic and environment interaction. Since there is paucity of data on asthma inheritance in Indian population, the present study was undertaken to investigate the inheritance patterns of asthma and the effect of family history and consanguineous marriage on asthma inheritance. A total of 200 families, 100 index children and 100 index adults with clinically diagnosed asthma, along with 400 non-asthmatic children and adults as controls were selected for the present study. Information about the family history of each patients and controls was collected and analyzed pedigrees were also constructed. A history of asthma in any member of the family was observed in 44.5 per cent of cases and 5.3 per cent of controls (P
ISSN:0971-5916