Not just a circle: flux modes in the plant TCA cycle

The tricarboxylic acid (TCA) cycle is one of the iconic pathways in metabolism. The cycle is commonly thought of in terms of energy metabolism, being responsible for the oxidation of respiratory substrates to drive ATP synthesis. However, the reactions of carboxylic acid metabolism are embedded in a...

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Bibliographic Details
Published in:Trends in plant science 2010-08, Vol.15 (8), p.462-470
Main Authors: Sweetlove, Lee J., Beard, Katherine F.M., Nunes-Nesi, Adriano, Fernie, Alisdair R., Ratcliffe, R. George
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carboxylic Acids - metabolism
Citric Acid Cycle
Fundamental and applied biological sciences. Psychology
Plant Cells
Plant Leaves - metabolism
Plant Physiological Phenomena
Plants - metabolism
Seeds - metabolism
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Summary:The tricarboxylic acid (TCA) cycle is one of the iconic pathways in metabolism. The cycle is commonly thought of in terms of energy metabolism, being responsible for the oxidation of respiratory substrates to drive ATP synthesis. However, the reactions of carboxylic acid metabolism are embedded in a larger metabolic network and the conventional TCA cycle is only one way in which the component reactions can be organised. Recent evidence from labelling studies and metabolic network models suggest that the organisation of carboxylic acid metabolism in plants is highly dependent on the metabolic and physiological demands of the cell. Thus, alternative, non-cyclic flux modes occur in leaves in the light, in some developing oilseeds, and under specific physiological circumstances such as anoxia.
ISSN:1360-1385
1878-4372
DOI:10.1016/j.tplants.2010.05.006