Regional variation in the free amino acids in the stratum corneum

Regional differences in water-binding free amino acids (FAAs) in the stratum corneum (SC) may be expected, since differences in skin biophysical properties are well known. The objective was to determine whether differences in skin hydration as a function of body site may arise from differences in th...

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Bibliographic Details
Published in:Journal of cosmetic science 2010-07, Vol.61 (4), p.303-309
Main Authors: Visscher, Marty, Robinson, Marisa, Wickett, R Randall
Format: Article
Language:English
Subjects:
Adult
Amino Acids - analysis
Amino Acids - metabolism
Female
Humans
Keratins - chemistry
Keratins - metabolism
Linear Models
Middle Aged
Skin - anatomy & histology
Skin - chemistry
Skin - metabolism
Young Adult
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Summary:Regional differences in water-binding free amino acids (FAAs) in the stratum corneum (SC) may be expected, since differences in skin biophysical properties are well known. The objective was to determine whether differences in skin hydration as a function of body site may arise from differences in the chemical makeup of the skin, specifically the FAAs. Levels were quantified from serial SC samples collected from the forearm, calf, back, torso, and jaw in two studies using HPLC methods. FAA levels were higher from the calf versus the forearm and lower from the jaw compared to torso and back skin. Body site variations in skin hydration could not be attributed to differences in FAA levels.
ISSN:1525-7886