Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated,...

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Bibliographic Details
Published in:Optics letters 2010-08, Vol.35 (16), p.2771-2773
Main Authors: XU, D.-X, VACHON, M, LIU, Q. Y, CHEBEN, P, SCHMID, J. H, DENSMORE, A, MA, R, DELAGE, A, JANZ, S, LAPOINTE, J, LI, Y, LOPINSKI, G, ZHANG, D
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biosensing Techniques - instrumentation
Cattle
Exact sciences and technology
Immunoglobulin G - immunology
Microtechnology
Optical telecommunications
Serum Albumin, Bovine - analysis
Serum Albumin, Bovine - immunology
Silicon
Telecommunications
Telecommunications and information theory
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Summary:We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.35.002771