A Community-based RCT for Oral Cancer Screening with Toluidine Blue

Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and...

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Bibliographic Details
Published in:Journal of dental research 2010-09, Vol.89 (9), p.933-937
Main Authors: Su, W.W.-Y., Yen, A.M.-F., Chiu, S.Y.-H., Chen, T.H.-H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Areca
Biological and medical sciences
Chi-Square Distribution
Coloring Agents
Confidence Intervals
Dentistry
Early Detection of Cancer
Humans
Leukoplakia, Oral - diagnosis
Male
Mass Screening - methods
Medical sciences
Middle Aged
Mouth Neoplasms - diagnosis
Oral Submucous Fibrosis - diagnosis
Otorhinolaryngology. Stomatology
Precancerous Conditions - diagnosis
Smoking
Tolonium Chloride
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Young Adult
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Summary:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10−5) was non-significantly 21% lower than that in the control group (35.4 x 10−5).
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034510373763